Mesterolone Classification Essay

Names
IUPAC name

6,7,8,9,10,10-Hexachloro-1,5,5a,6,9,9a-hexahydro- 6,9-methano-2,4,3-benzodioxathiepine-3-oxide

Other names

Benzoepin, Endocel, Parrysulfan, Phaser, Thiodan, Thionex

Identifiers

CAS Number

3D model (JSmol)

ChEBI
ChemSpider
ECHA InfoCard100.003.709
KEGG
UNII

InChI

  • InChI=1S/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2/t3-,4-,7-,8+,19+/m0/s1 Y
    Key: RDYMFSUJUZBWLH-QDLMHMFQSA-N Y
  • InChI=1/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2

    Key: RDYMFSUJUZBWLH-UHFFFAOYAH

  • InChI=1/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2/t3-,4-,7-,8+,19+/m0/s1

    Key: RDYMFSUJUZBWLH-QDLMHMFQBI

SMILES

  • Cl[C@@]3(Cl)[C@]1(Cl)C(/Cl)=C(/Cl)[C@@]3(Cl)[C@H]2[C@@H2]OS(=O)O[C@@H2][C@H]12

Properties

Chemical formula

C9H6Cl6O3S
Molar mass406.90 g·mol−1
AppearanceBrown crystals[1]
Odorslight sulfur dioxide odor[1]
Density1.745 g/cm3
Melting point70 to 100 °C (158 to 212 °F; 343 to 373 K)
Boiling pointdecomposes[1]

Solubility in water

0.33 mg/L
Vapor pressure0.00001 mmHg (25 °C)[1]
Hazards
Main hazardsT, Xi, N

EU classification (DSD) (outdated)

Yes (T, Xi, N)
R-phrases(outdated)R24/25R36R50/53
NFPA 704
Flash pointnoncombustible [1]
US health exposure limits (NIOSH):

PEL (Permissible)

none[1]

REL (Recommended)

TWA 0.1 mg/m3 [skin][1]

IDLH (Immediate danger)

N.D.[1]

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N verify (what is YN ?)
Infobox references

Endosulfan is an off-patentorganochlorineinsecticide and acaricide that is being phased out globally. The two isomers, endo and exo, are known popularly as I and II. Endosulfan sulfate is a product of oxidation containing one extra O atom attached to the S atom. Endosulfan became a highly controversial agrichemical[2] due to its acute toxicity, potential for bioaccumulation, and role as an endocrine disruptor. Because of its threats to human health and the environment, a global ban on the manufacture and use of endosulfan was negotiated under the Stockholm Convention in April 2011. The ban has taken effect in mid-2012, with certain uses exempted for five additional years.[3] More than 80 countries,[4] including the European Union, Australia, New Zealand, several West African nations,[5] the United States,[6][7] Brazil,[8] and Canada[9] had already banned it or announced phase-outs by the time the Stockholm Convention ban was agreed upon. It is still used extensively in India, China, and few other countries. It is produced by Makhteshim Agan and several manufacturers in India and China. Although, the Supreme Court had, by an order dated 13.05.2011, put a ban on the production and sale of endosulfan in India till further orders.[10]

Uses[edit]

Endosulfan has been used in agriculture around the world to control insect pests including whiteflies, aphids, leafhoppers, Colorado potato beetles and cabbage worms.[11] Due to its unique mode of action, it is useful in resistance management; however, as it is not specific, it can negatively impact populations of beneficial insects.[12] It is, however, considered to be moderately toxic to honey bees,[13] and it is less toxic to bees than organophosphate insecticides.[14]

Production[edit]

The World Health Organization estimated worldwide annual production to be about 9,000 metric tonnes (t) in the early 1980s.[15] From 1980 to 1989, worldwide consumption averaged 10,500 tonnes per year, and for the 1990s use increased to 12,800 tonnes per year.

Endosulfan is a derivative of hexachlorocyclopentadiene, and is chemically similar to aldrin, chlordane, and heptachlor. Specifically, it is produced by the Diels-Alder reaction of hexachlorocyclopentadiene with cis-butene-1,4-diol and subsequent reaction of the adduct with thionyl chloride. Technical endosulfan is a 7:3 mixture of stereoisomers, designated α and β. α- and β-Endosulfan are configurational isomers arising from the pyramidal stereochemistry of the teravalent sulfur. α-Endosulfan is the more thermodynamically stable of the two, thus β-endosulfan irreversibly converts to the α form, although the conversion is slow.[16][17]

History of commercialization and regulation[edit]

  • Early 1950s: Endosulfan was developed.
  • 1954: Hoechst AG (now Sanofi) won USDA approval for the use of endosulfan in the United States.[18]
  • 2000: Home and garden use in the United States was terminated by agreement with the EPA.[14]
  • 2002: The U.S. Fish and Wildlife Service recommended that endosulfan registration should be cancelled,[19] and the EPA determined that endosulfan residues on food and in water pose unacceptable risks. The agency allowed endosulfan to stay on the US market, but imposed restrictions on its agricultural uses.[14]
  • 2007: International steps were taken to restrict the use and trade of endosulfan. It is recommended for inclusion in the Rotterdam Convention on Prior Informed Consent,[20] and the European Union proposed inclusion in the list of chemicals banned under the Stockholm Convention on Persistent Organic Pollutants. Such inclusion would ban all use and manufacture of endosulfan globally.[21] Meanwhile, the Canadian government announced that endosulfan was under consideration for phase-out,[22] and Bayer CropScience voluntarily pulled its endosulfan products from the U.S. market[23] but continues to sell the products elsewhere.[24]
  • 2008: In February, environmental, consumer, and farm labor groups including the Natural Resources Defense Council,[25]Organic Consumers Association, and the United Farm Workers[26] called on the U.S. EPA to ban endosulfan. In May, coalitions of scientists,[27] environmental groups, and arctic tribes asked the EPA to cancel endosulfan,[28] and in July a coalition of environmental and workers groups filed a lawsuit against the EPA challenging its 2002 decision to not ban it.[29] In October, the Review Committee of the Stockholm Convention moved endosulfan along in the procedure for listing under the treaty,[30] while India blocked its addition to the Rotterdam Convention.[31]
  • 2009: The Stockholm Convention's Persistent Organic Pollutants Review Committee (POPRC) agreed that endosulfan is a persistent organic pollutant and that "global action is warranted", setting the stage of a global ban.[32] New Zealand banned endosulfan.[33]
  • 2010: The POPRC nominated endosulfan to be added to the Stockholm Convention at the Conference of Parties (COP) in April 2011, which would result in a global ban.[34] The EPA announced that the registration of endosulfan in the U.S. will be cancelled[7][35] Australia banned the use of the chemical.[36]
  • 2011: The Supreme Court of India banned manufacture, sale, and use of toxic pesticide endosulfan in India. The apex court said the ban would remain effective for eight weeks during which an expert committee headed by DG, ICMR, will give an interim report to the court about the harmful effect of the widely used pesticide.[37]
  • 2011: the Argentinian Service for Sanity and Agroalimentary Quality (SENASA) decided on August 8 that the import of endosulfan into the South American country will be banned from July 1, 2012 and its commercialization and use from July 1, 2013. In the meantime, a reduced quantity can be imported and sold.[38]

Health effects[edit]

Endosulfan is one of the most toxic pesticides on the market today, responsible for many fatal pesticide poisoning incidents around the world.[39] Endosulfan is also a xenoestrogen—a synthetic substance that imitates or enhances the effect of estrogens—and it can act as an endocrine disruptor, causing reproductive and developmental damage in both animals and humans.[40] It has also been found to act as an aromatase inhibitor.[40] Whether endosulfan can cause cancer is debated. With regard to consumers' intake of endosulfan from residues on food, the Food and Agriculture Organization of United Nations has concluded that long-term exposure from food is unlikely to present a public health concern, but short-term exposure can exceed acute reference doses.[41]

Toxicity[edit]

Endosulfan is acutely neurotoxic to both insects and mammals, including humans. The US EPA classifies it as Category I: "Highly Acutely Toxic" based on a LD50 value of 30 mg/kg for female rats,[14] while the World Health Organization classifies it as Class II "Moderately Hazardous" based on a rat LD50 of 80 mg/kg.[42] It is a GABA-gated chloride channelantagonist, and a Ca2+, Mg2+ATPaseinhibitor. Both of these enzymes are involved in the transfer of nerve impulses. Symptoms of acute poisoning include hyperactivity, tremors, convulsions, lack of coordination, staggering, difficulty breathing, nausea and vomiting, diarrhea, and in severe cases, unconsciousness.[18] Doses as low as 35 mg/kg have been documented to cause death in humans,[43] and many cases of sublethal poisoning have resulted in permanent brain damage.[18] Farm workers with chronic endosulfan exposure are at risk of rashes and skin irritation.[14]

EPA's acute reference dose for dietary exposure to endosulfan is 0.015 mg/kg for adults and 0.0015 mg/kg for children. For chronic dietary expsoure, the EPA references doses are 0.006 mg/(kg·day) and 0.0006 mg/(kg·day) for adults and children, respectively.[14]

Endocrine disruption[edit]

Theo Colborn, an expert on endocrine disruption, lists endosulfan as a known endocrine disruptor,[44] and both the EPA and the Agency for Toxic Substances and Disease Registry consider endosulfan to be a potential endocrine disruptor. Numerous in vitro studies have documented its potential to disrupt hormones and animal studies have demonstrated its reproductive and developmental toxicity, especially among males.[14][18] A number of studies have documented that it acts as an antiandrogen in animals.[40][45] Endosulfan has shown to affect crustacean molt cycles, which are important biological and endocrine-controlled physiological processes essential for the crustacean growth and reproduction.[46] Environmentally relevant doses of endosulfan equal to the EPA's safe dose of 0.006 mg/kg/day have been found to affect gene expression in female rats similarly to the effects of estrogen.[47] It is not known whether endosulfan is a human teratogen (an agent that causes birth defects), though it has significant teratogenic effects in laboratory rats.[48] A 2009 assessment concluded the endocrine disruption in rats occurs only at endosulfan doses that cause neurotoxicity.[49]

Reproductive and developmental effects[edit]

Several studies have documented that endosulfan can also affect human development. Researchers studying children from many villages in Kasargod District, Kerala, India, have linked endosulfan exposure to delays in sexual maturity among boys. Endosulfan was the only pesticide applied to cashew plantations in the villages for 20 years, and had contaminated the village environment. The researchers compared the villagers to a control group of boys from a demographically similar village that lacked a history of endosulfan pollution. Relative to the control group, the exposed boys had high levels of endosulfan in their bodies, lower levels of testosterone, and delays in reaching sexual maturity. Birth defects of the male reproductive system, including cryptorchidism, were also more prevalent in the study group. The researchers concluded, "our study results suggest that endosulfan exposure in male children may delay sexual maturity and interfere with sex hormone synthesis."[50] Increased incidences of cryptorchidism have been observed in other studies of endosulfan exposed populations.[51][52]

A 2007 study by the California Department of Public Health found that women who lived near farm fields sprayed with endosulfan and the related organochloride pesticide dicofol during the first eight weeks of pregnancy are several times more likely to give birth to children with autism. This is the first study to look for an association between endosulfan and autism, and additional study is needed to confirm the connection.[53] A 2009 assessment concluded that epidemiology and rodent studies that suggest male reproductive and autism effects are open to other interpretations, and that developmental or reproductive toxicity in rats occurs only at endosulfan doses that cause neurotoxicity.[49]

Endosulfan and cancer[edit]

Endosulfan is not listed as known, probable, or possible carcinogen by the EPA, IARC, or other agencies. No epidemiological studies link exposure to endosulfan specifically to cancer in humans, but in vitro assays have shown that endosulfan can promote proliferation of human breast cancer cells.[54] Evidence of carcinogenicity in animals is mixed.[18]

In a 2016 study[55] by the Department of Biochemistry, Indian Institute of Science, Bangalore published in Carcinogenesis, Endosulfan was found to induce reactive oxygen species (ROS) in a concentration and time-dependent manner leading to double-stranded breaks in the DNA and also found to favour subsequent erroneous DNA repair.

Environmental fate[edit]

Endosulfan is a ubiquitous environmental contaminant. The chemical is semivolatile and persistent to degradation processes in the environment. Endosulfan is subject to long-range atmospheric transport, i.e. it can travel long distances from where it is used. Thus, it occurs in many environmental compartments. For example, a 2008 report by the National Park Service found that endosulfan commonly contaminates air, water, plants, and fish of national parks in the US. Most of these parks are far from areas where endosulfan is used.[56] Endosulfan has been found in remote locations such as the Arctic Ocean, as well as in the Antarctic atmosphere.[57] The pesticide has also been detected in dust from the Sahara Desert collected in the Caribbean after being blown across the Atlantic Ocean.[58] The compound has been shown to be one of the most abundant organochlorine pesticides in the global atmosphere.[57]

The compound breaks down into endosulfan sulfate, endosulfan diol, and endosulfan furan, all of which have structures similar to the parent compound and, according to the EPA, "are also of toxicological concern…The estimated half-lives for the combined toxic residues (endosulfan plus endosulfan sulfate) [range] from roughly 9 months to 6 years." The EPA concluded, "[b]ased on environmental fate laboratory studies, terrestrial field dissipation studies, available models, monitoring studies, and published literature, it can be concluded that endosulfan is a very persistent chemical which may stay in the environment for lengthy periods of time, particularly in acid media." The EPA also concluded, "[e]ndosulfan has relatively high potential to bioaccumulate in fish."[14] It is also toxic to amphibians; low levels have been found to kill tadpoles.[59]

In 2009, the committee of scientific experts of the Stockholm Convention concluded, "endosulfan is likely, as a result of long range environmental transport, to lead to significant adverse human health and environmental effects such that global action is warranted."[60] In May 2011, the Stockholm Convention committee approved the recommendation for elimination of production and use of endosulfan and its isomers worldwide. This is, however, subject to certain exemptions. Overall, this will lead to its elimination from the global markets.[61]

Status by region[edit]

India[edit]

Although classified as a yellow label (highly toxic) pesticide by the Central Insecticides Board, India is one of the largest producers[62] and the largest consumer of endosulfan in the world.[11] Of the total volume manufactured in India, three companies — Excel Crop Care, Hindustan Insecticides Ltd, and Coromandal Fertilizers — produce 4,500 tonnes annually for domestic use and another 4,000 tonnes for export. Endosulfan is widely used in most of the plantation crops in India. The toxicity of endosulfan and health issues due to its bioaccumulation came under media attention when health issues precipitated in the Kasargod District (of Kerala) were publicised.[63][64] This inspired protests, and the pesticide was banned in Kerala as early as 2001, following a report by the National Institute of Occupational Health. In the Stockholm Convention on Persistent Organic Pollutants of 2011, when an international consensus arose for the global ban of the pesticide, India opposed this move due to pressure from the endosulfan manufacturing companies.[21][65] This flared up the protest,[66][67][68] and while India still maintained its stance, the global conference decided on a global ban, for which India asked a remission for 10 years. Later, on a petition filed in the Supreme Court of India, the production, storage, sale and use of the pesticide was temporarily banned on 13 May 2011, and later permanently by the end of 2011.[69][70]

The Karnataka government also banned the use of endosulfan with immediate effect. Briefing presspersons after the State Cabinet meeting, Minister for Higher Education V.S. Acharya said the Cabinet discussed the harmful effects of endosulfan on the health of farmers and people living in rural areas. The government will now invoke the provisions of the Insecticides Act, 1968 (a Central act) and write a letter to the Union Government about the ban. Minister for Energy, and Food and Civil Supplies Shobha Karandlaje, who has been spearheading a movement seeking a ban on endosulfan, said, "I am grateful to Chief Minister B.S. Yeddyurappa and members of the Cabinet for approving the ban.[71]

Rajendra Singh Rana has written a letter to Prime MinisterManmohan Singh demanding the withdrawal of the National Institute of Occupational Health (NIOH) study on Endosulfan titled "Report Of The Investigation Of Unusual Illness" allegedly produced by the Endosulfan exposure in Padre village of Kasargod district in north Kerala. In his statement Mr. Rana said "The NIOH report is flawed. I'm in complete agreement with what the workers have to say on this. In fact, I have already made representation to the Prime Minister and concerned Union Ministers of health and environment demanding immediate withdrawal of the report," as reported by The Economic Times and Outlook India[72][73]

Mrs. Vibhavari Dave, local leader and Member of Legislative Assembly (MLA), from Bhavnagar, Gujarat, voiced her concerns on the impact of ban of endosulfan on families and workers of Bhavnagar. She was a part of the delegation with Bhavnagar MP, Rajendra Singh Rana, which submitted a memorandum to the district collector's office to withdraw the NIOH report calling for ban of endosulfan.[74][75] The Pollution Control Board of the Government of Kerala, prohibited the use of endosulfan in the state of Kerala on 10 November 2010.[76] On February 18, 2011, the Karnataka government followed suit and suspended the use of endosulfan for a period of 60 days in the state.[77] Indian Union Minister of Agriculture Sharad Pawar has ruled out implementing a similar ban at the national level despite the fact that endosulfan has banned in 63 countries, including the European Union, Australia, and New Zealand.[78]

The Government of Gujarat had initiated a study in response to the workers' rally in Bhavnagar and representations made by Sishuvihar, an NGO based in Ahmadabad. The committee constituted for the study also included former Deputy Director of NIOH, Ahmadabad. The committee noted that the WHO, FAO, IARC and US EPA have indicated that endosulfan is not carcinogenic, not teratogenic, not mutagenic and not genotoxic. The highlight of this report is the farmer exposure study based on analysis of their blood reports for residues of endosulfan and the absence of any residues. This corroborates the lack of residues in worker-exposure studies.[79][80]

The Supreme Court passed interim order on May 13, 2011, in a Writ Petition filed by Democratic Youth Federation of India, (DYFI), a youth wing of Communist Party of India (Marxist) in the backdrop of the incidents reported in Kasargode, Kerala, and banned the production, distribution and use of endosulfan in India because the pesticide has debilitating effects on humans and the environment.[69][70] The Centre for Science and Environment (CSE) welcomed this order, and called it a 'resounding defeat' for the pesticide industry which has been promoting this deadly toxin. A 2001 study by CSE had established the linkages between the aerial spraying of the pesticide and the growing health disorders in Kasaragode.Over the years, other studies have confirmed these findings, and the health hazards associated with endosulfan are now widely known and accepted. However, in July 2012, the Government asked the Supreme Court to allow use of the pesticide in all states except Kerala and Karnataka, as these states are ready to use it for pest control.[81] But the court did not consider this request. India will phase out all endosulfan use by 2017.[82] On January 10, 2017, The Supreme Court ordered the State Governments to release the remaining undisbursed payment of compensation quantified (Rupees Five lakhs each) to all the affected persons within three months.[83]

New Zealand[edit]

Endosulfan was banned in New Zealand by the Environmental Risk Management Authority effective January 2009[33] after a concerted campaign by environmental groups and the Green Party.

See also: Pesticides in New Zealand

Philippines[edit]

A shipment of about 10 tonnes of endosulfan was illegally stowed on the ill-fated MV Princess of the Stars, a ferry that sank off the waters of Romblon (Sibuyan Island), Philippines, during a storm in June 2008. Search, rescue, and salvage efforts were suspended when the endosulfan shipment was discovered, and blood samples from divers at the scene were sent to Malaysia for analysis.[84] The Department of Health of the Philippines has temporarily banned the consumption of fish caught in the area.[85] Endosulfan is classified as a "Severe Marine Pollutant" by the International Maritime Dangerous Goods Code.[20]

United States[edit]

In the United States, endosulfan is only registered for agricultural use, and these uses are being phased out.[7] It has been used extensively on cotton, potatoes, tomatoes, and apples according to the EPA.[86] The EPA estimates that 626 thousand kg of endosulfan were used annually from 1987 to 1997.[14] The US exported more than 140,000 lb of endosulfan from 2001 to 2003, mostly to Latin America,[87] but production and export has since stopped.

In California, endosulfan contamination from the San Joaquin Valley has been implicated in the extirpation of the mountain yellow-legged frog from parts of the nearby Sierra Nevada.[88] In Florida, levels of contamination the Everglades and Biscayne Bay are high enough to pose a threat to some aquatic organisms.[89][90][91]

In 2007, the EPA announced it was rereviewing the safety of endosulfan.[92] The following year, Pesticide Action Network and NRDC petitioned the EPA to ban endosulfan,[93] and a coalition of environmental and labor groups sued the EPA seeking to overturn its 2002 decision to not ban endosulfan.[29] In June 2010, the EPA announced it was negotiating a phaseout of all uses with the sole US manufacturer, Makhteshim Agan, and a complete ban on the compound.[7]

An official statement by Makhteshim Agan of North America (MANA) states, "From a scientific standpoint, MANA continues to disagree fundamentally with EPA's conclusions regarding endosulfan and believes that key uses are still eligible for re-registration." The statement adds, "However, given the fact that the endosulfan market is quite small and the cost of developing and submitting additional data high, we have decided to voluntarily negotiate an agreement with EPA that provides growers with an adequate time frame to find alternatives for the damaging insect pests currently controlled by endosulfan." [94][95]

Australia[edit]

Australia banned endosulfan on October 12, 2010,[96][97][98] with a two-year phase-out for stock of endosulfan-containing products.[96] Australia had, in 2008, announced endosulfan would not be banned.[99] Citing New Zealand's ban, the Australian Greens called for "zero tolerance" of endosulfan residue on food.[5]

Taiwan[edit]

US apples with endosulfan are now allowed to be exported to Taiwan, although the ROC government denied any US pressure on it.[100]

Brazil[edit]

Brazil decreed total ban of the substance from July 31, 2013, being forbidden imports of the product from July 31, 2011, date in which national production and utilization begins to be phased out gradually.[101]

References[edit]

  1. ^ abcdefgh"NIOSH Pocket Guide to Chemical Hazards #0251". National Institute for Occupational Safety and Health (NIOSH). 
  2. ^"Bayer to stop selling endosulfan". Australian Broadcasting Corporation. July 17, 2009. Retrieved 2009-07-17. 
  3. ^http://www.thehindu.com/news/national/article1968299.ece
  4. ^"Endosulfan: Supreme Court to hear seeking ban on Monday". The Hindu. Chennai, India. 1 May 2011. Retrieved 2 May 2011. 
  5. ^ ab"Australia should ban endosulfan: Greens". Weekly Times. News Limited. January 8, 2009. Retrieved 2009-01-08. 
  6. ^Cone, Marla. EPA Bans Pesticide Found on Cucumbers, Zucchini, Green Beans and Other Vegetables.The Daily Green. June 10, 2010.
  7. ^ abcd"EPA Action to Terminate Endosulfan". United States Environmental Protection Agency. Retrieved 10 June 2010. 
  8. ^http://www.agrow.com/markets/southamerica/Endosulfan-ban-in-Brazil-from-2013-299753?autnRef=/contentstore/agrow/codex/0bef898a-90fc-11df-870a-bbcce1c03e31.xml
  9. ^PMRA: Re-evaluation Note REV2011-01, Discontinuation of Endosulfan http://www.hc-sc.gc.ca/cps-spc/pubs/pest/_decisions/rev2011-01/index-eng.php
  10. ^http://pib.nic.in/newsite/PrintRelease.aspx?relid=107462
  11. ^ abGovernment of Canada (January 10, 2009). "Endosulfan: Canada's submission of information specified in Annex E of". Retrieved 2009-01-29. 
  12. ^Mossler, Mark; Michael J. Aerts; O. Norman Nesheim (March 2006). "Florida Crop/Pest Management Profiles: Tomatoes. CIR 1238"(PDF). University of Florida, IFAS Extension. Retrieved 2009-01-27. 
  13. ^Extension Toxicology Network (June 1996). "Pesticide Information Profile: Endosulfan". Oregon State University. 
  14. ^ abcdefghiUS EPA, Reregistration Eligibility Decision for EndosulfanArchived 2006-10-06 at the Wayback Machine., November 2002.
  15. ^World Health Organization, Environmental Health Criteria 40, 1984.
  16. ^(a) Schmidt WF, Hapeman CJ, Fettinger JC, Rice CP, and Bilboulian S, J. Ag. Food Chem., 1997, 45(4): 1023–1026.
    (b) Schmidt WF, Bilboulian S, Rice CP, Fettinger JC, McConnell LL, and Hapeman CJ, J. Ag. Food Chem., 2001, 49(11): 5372–5376.
  17. ^Robert L. Metcalf "Insect Control" in Ullmann's Encyclopedia of Industrial Chemistry" Wiley-VCH, Weinheim, 2002. doi:10.1002/14356007.a14_263
  18. ^ abcdeAgency of Toxic Substances and Disease Registry, Toxicological Profile for Endosulfan, 2000.
  19. ^Kay, Jane (March 2, 2006). "A move to ease pesticide laws". San Francisco Chronicle. pp. A1. .
  20. ^ abSecretariat for the Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade (16 October 2007). "Draft Decision Guidance Document"(PDF). United Nations Environment Programme. Archived from the original(PDF) on 27 March 2009. Retrieved 2008-10-06. 
  21. ^ ab"SUMMARY OF THE FOURTH MEETING OF THE PERSISTENT ORGANIC POLLUTANTS REVIEW COMMITTEE OF THE STOCKHOLM CONVENTION". Earth Negotiations Bulletin. 15 (161). October 20, 2008. 
  22. ^Canada to end endosulfan use?Agrow, Oct 22, 2007.
  23. ^Note to Reader. Endosulfan: Request for Additional Information on Usage and Availability of AlternativesArchived March 27, 2009, at the Wayback Machine., U.S. EPA, Nov. 16, 2007.
  24. ^Our Products: Endosulfan, BayerCropScience.com, Accessed 03/03/08.
  25. ^PETITION TO BAN ENDOSULFAN AND REVOKE ALL TOLERANCES AND COMMENTS ON THE ENDOSULFAN UPDATED RISK ASSESSMENT (OPP-2002-0262-0067) BY THE NATURAL RESOURCES DEFENSE COUNCIL, National Resources Defense Council, Feb. 2008.
  26. ^Thousands Tell EPA: Phase Out EndosulfanArchived May 17, 2008, at the Wayback Machine., Pesticide Action Network, Feb. 18, 2008
  27. ^Sass J, Janssen S; Janssen (2008). "Open letter to Stephen Johnson, Administrator, U.S. Environmental Protection Agency: ban endosulfan". Int J Occup Environ Health. 14 (3): 236–9. doi:10.1179/oeh.2008.14.3.236. PMID 18686727. 
  28. ^Erickson, Britt (May 21, 2008). "Groups Petition EPA To Ban Endosulfan". Chemical and Engineering News. 
  29. ^ ab"Group sues to ban DDT-related pesticide". The Mercury News. Retrieved 2008-08-11. [dead link]
  30. ^POPRC-4 — Summary and Analysis, 20 October 2008[permanent dead link], The International Institute for Sustainable Development – Reporting Services Division.
  31. ^Dutta, Mahdumita (November 21, 2008). "To Industry's Tune". Down to Earth. Retrieved 2008-11-22. 
Endosulfan use in the US in pounds per square mile by county in 2013
Endosulfan use in the US in pounds per square mile by county in 2002

How should I go about choosing my topic?

Begin by reading the explanations below.  Examples of each are provided below!

  • Division Essay: find a topic that people might tend to underestimate or over-simplify.  In other words, choose something that the average person might not know much about, and therefore can't really understand how complex or interesting that topic really is.  Your job in the essay will be to break your topic down into meaningful and important categories.

  • Classification Essay: think about the categories we place things in everyday and the characteristics of those categories.  The topic you choose should allow you to argue that something has been misplaced.

How should I organize this essay?

As you write, keep these guidelines in mind: 

  1. Your thesis statement and introduction will need to explain why these divisions/ classifications should matter to your reader.
  2. Your thesis statement and introduction MUST define or explain the category you plan to discuss (i.e. A sport is a competitive, physical activity therefore cheerleading should be considered a sport.)
  3. You should organize your body paragraphs so that each division or category has it's own paragraph or section. (i.e. cardio exercise is paragraph 1 and weightlifting is paragraph 2, etc.)

Division Essay Examples

If you want to lose weight, simply saying that you're going to "exercise" everyday may not be the most effective way to do so.  Exercising is more complex than many people realize--attaining your goals will involve understanding how different types of exercise can help you achieve your goals.   

Types of Exercise

  • cardio: burns calories and strengthens your heart (running, using an elliptical or stair-stepping machine, etc.)
  • weight lifting: tones muscles, increases physical strength, burns fat (using weights or weighted machines)
  • recreational/sports: depending on the sport, can provide both cardio and toning benefits (cycling, tennis, kayaking)

We could also narrow this topic down a bit further and write about the important differences between different types of cycling.

Types of Cycling:  stationary (exercise) biking, road biking, mountain biking, recreational biking

Classification Essay Examples

To write this type of essay, we'll need to think about things that should or should not be placed in a particular category.

Example: Batman (that's our topic!) is not a superhero (category people place him in), but is simply a local vigilante (category he belongs in).

Ask yourself: Why do I think that...?

  • Does not possess super powers (powers most humans don't possess).  
  • Chooses to be a hero, rather than being "chosen" by others/other forces.

Example: Cheerleading (That's our topic!) should be considered a sport (It belongs in the category, "sports"). 

Ask yourself: Why do I think that...?

  • cheerleaders go to "practice" and must be in good physical shape
  • cheerleaders work together toward a common goal
  • cheerleaders must "try out" for their squad and often compete against other squads

Sample Papers

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